Melvin, a reluctant Superhero, lives only for crime, women and drugs - until he realises that the only way he will ever get to see his estranged son is to go straight and fulfil his potential as a crime fighter.

Jeff, at 30, lives in his mom's basement, unemployed, looking for signs about what to do with his life. He answers a wrong-number call for "Kevin". Later, on a bus, he sees someone wearing a jersey with "Kevin" on the back. Jeff follows him. Meanwhile, Jeff's brother, Pat, a tone-deaf salesman, upsets his wife by buying a Porsche they cannot afford; Pat runs into Jeff soon after and they see Pat's wife with another man. At her job, Jeff and Pat's mom receives e-mails from a secret admirer; she tries to figure out who it is. Misunderstandings, errors, and confrontations abound. A backup on the Lake Pontchartrain Causeway brings things to a head.

Four individuals sign up for a psychological research study only to discover that they are now subjects of a brutal, classified government program.